Viral infections in pregnancy.
نویسنده
چکیده
The importance of protecting pregnant women from infection as well as from possible harmful effects of various medications and other noxious agents has received increasing attention in recent years. Much of the work related to viral diseases has been directed toward (1) identifying the agents that might be associated with fetal wastage and congenital malformations; (2) determining the risk to the fetus when women are infected during pregnancy; (3) elucidating the pathogenesis of fetal infections; and (4) considering means of control by vaccination or other measures when feasible. There has been little statistically valid information on the incidence of viral infections in pregnancy. In a six year prospective survey of some 30,000 pregnant women, investigators in the Collaborative Perinatal Research Study attempted to assess the actual frequency of viral infection in this group.' Clinical information on the occurrence of various types of illness was collected and paired serum specimens (taken at the first prenatal visit and at the time of delivery) were examined for the development of antibodies against a number of common viruses. Some 1,600 of the women reported illness presumed viral, excluding episodes of the common cold. Most were acute influenza-like respiratory infections, herpes simplex, and a variety of nonspecific syndromes. The incidence of specific diseases was low. Serologic tests confirmed the clinical diagnoses and gave the following minimum attack rates per 10,000: 10 for mumps, 8 for rubella, 5 for vari-cella zoster, and 0.6 for measles. Inapparent infections were also documented by serologic means. In one group of 2,000 women, there were significant complement fixing antibody rises to cytomegalovirus in 3 percent; to influenza B in 4.4 percent; and to adenoviruses in 1.4 percent. Unfortunately it was not possible in this study to document the influence of infection in the early months of pregnancy since women usually are not seen for prenatal care until late in the first trimester. Nevertheless the above results provide some indication of the size of the problem. Infection during pregnancy can be viewed in terms of its significance for the mother-i.e. increased morbidity and mortality, or in relation to its effects on the fetus. The range includes no involvement, or fetal infection
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عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 42 شماره
صفحات -
تاریخ انتشار 1969